Provide and coordinate patient care, educate patients, and provide emotional support. Median salary in Columbia: $75K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in Columbia, South Carolina. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Registered Nurses in Columbia earn approximately 9% lower than the US national median for this role — a $7,000 discount on annual base salary. Columbia's lower wage level partially reflects the area's cost-of-living index of 88 (US avg = 100).
Adjusted for Columbia's cost-of-living index (88), the median Registered Nurse salary buys the equivalent of $85,227 in a US-average-cost city. That's $3,227 more purchasing power than the national median — a meaningful real-wage advantage.
Average 1-bedroom rent in Columbia ($1,100/mo) consumes approximately 28% of an after-tax median Registered Nurse salary. Financial planners typically recommend keeping housing under 30% of take-home — a salary at the 75th percentile ($96K) brings that ratio into a more comfortable range here.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $88K by 2030.
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The median Registered Nurse salary in Columbia, SC is $75,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the Columbia–SC metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Registered Nurses in Columbia with 0–2 years of experience typically earn between $60,000 and $75,000 annually. Mid-career professionals with 3–7 years command $75,000 to $96,000, while senior-level practitioners with 8+ years of experience regularly earn $96,000 to $120,000 or more.
Columbia has a cost of living index of 88 compared to the US national average of 100. This means your salary goes approximately 12% further in Columbia than the national average. South Carolina has a 6.5% state income tax rate.
BSN or ADN; RN licensure required. 8% of these roles offer some remote flexibility.