Provide advanced nursing care including diagnosis, treatment, and prescribing medications. Median salary in Des Moines: $115K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in Des Moines, Iowa. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Nurse Practitioners in Des Moines earn approximately 5% lower than the US national median for this role — a $6,000 discount on annual base salary. Des Moines's lower wage level partially reflects the area's cost-of-living index of 88 (US avg = 100).
Adjusted for Des Moines's cost-of-living index (88), the median Nurse Practitioner salary buys the equivalent of $130,682 in a US-average-cost city. That's $9,682 more purchasing power than the national median — a meaningful real-wage advantage.
Only 15% of Nurse Practitioner positions offer remote flexibility, meaning the Des Moines salary above represents what local employers actually pay — not a remote-anywhere rate. Geographic constraints reinforce the local market, so the salary range above is more directly applicable than for remote-friendly roles.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $115K by 2030.
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The median Nurse Practitioner salary in Des Moines, IA is $115,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the Des Moines–IA metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Nurse Practitioners in Des Moines with 0–2 years of experience typically earn between $95,000 and $115,000 annually. Mid-career professionals with 3–7 years command $115,000 to $138,000, while senior-level practitioners with 8+ years of experience regularly earn $138,000 to $166,000 or more.
Des Moines has a cost of living index of 88 compared to the US national average of 100. This means your salary goes approximately 12% further in Des Moines than the national average. Iowa has a 4.82% state income tax rate.
Master's or DNP; APRN licensure. 15% of these roles offer some remote flexibility.