Practice medicine under physician supervision — diagnosing, treating, and prescribing. Median salary in North Charleston: $129K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in North Charleston, South Carolina. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Adjusted for North Charleston's cost-of-living index (95), the median Physician Assistant salary buys the equivalent of $135,789 in a US-average-cost city. That's $5,789 more purchasing power than the national median — a meaningful real-wage advantage.
Only 5% of Physician Assistant positions offer remote flexibility, meaning the North Charleston salary above represents what local employers actually pay — not a remote-anywhere rate. Geographic constraints reinforce the local market, so the salary range above is more directly applicable than for remote-friendly roles.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $154K by 2030.
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The median Physician Assistant salary in North Charleston, SC is $129,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the North Charleston–SC metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Physician Assistants in North Charleston with 0–2 years of experience typically earn between $108,000 and $129,000 annually. Mid-career professionals with 3–7 years command $129,000 to $154,000, while senior-level practitioners with 8+ years of experience regularly earn $154,000 to $184,000 or more.
North Charleston has a cost of living index of 95 compared to the US national average of 100. This means your salary goes approximately 5% further in North Charleston than the national average. South Carolina has a 6.5% state income tax rate.
Master's in Physician Assistant Studies; PA-C certification. 5% of these roles offer some remote flexibility.