Practice medicine under physician supervision — diagnosing, treating, and prescribing. Median salary in Port St. Lucie: $127K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in Port St. Lucie, Florida. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Physician Assistants in Port St. Lucie earn approximately 2% lower than the US national median for this role — a $3,000 discount on annual base salary. Port St. Lucie's lower wage level partially reflects the area's cost-of-living index of 98 (US avg = 100).
Florida has no state income tax, which is worth roughly $11,811 per year at this salary level compared to a California Physician Assistant on the same gross pay. A Port St. Lucie Physician Assistant would need to earn $140,022 in California to net the same take-home.
Only 5% of Physician Assistant positions offer remote flexibility, meaning the Port St. Lucie salary above represents what local employers actually pay — not a remote-anywhere rate. Geographic constraints reinforce the local market, so the salary range above is more directly applicable than for remote-friendly roles.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $151K by 2030.
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The median Physician Assistant salary in Port St. Lucie, FL is $127,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the Port St. Lucie–FL metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Physician Assistants in Port St. Lucie with 0–2 years of experience typically earn between $106,000 and $127,000 annually. Mid-career professionals with 3–7 years command $127,000 to $152,000, while senior-level practitioners with 8+ years of experience regularly earn $152,000 to $181,000 or more.
Port St. Lucie has a cost of living index of 98 compared to the US national average of 100. This means your salary goes approximately 2% further in Port St. Lucie than the national average. Crucially, Florida has no state income tax — giving Port St. Lucie-based Physician Assistants an immediate 3–5% take-home pay advantage over workers in states like California (9.3%) or New York (6.85%).
Master's in Physician Assistant Studies; PA-C certification. 5% of these roles offer some remote flexibility.