Investigate the properties and composition of matter to develop new products and materials. Median salary in San Francisco: $116K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in San Francisco, California. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Chemists in San Francisco earn approximately 45% higher than the US national median for this role — a $36,000 premium on annual base salary. This reflects San Francisco's position as a higher-cost labor market where employers must match local wage norms.
Adjusted for San Francisco's cost-of-living index (224), the median Chemist salary buys the equivalent of $51,786 in a US-average-cost city. That's $28,214 less purchasing power than the national median — the higher nominal salary doesn't fully offset local costs.
California's 9.3% state income tax reduces take-home by roughly $10,788 per year at the median salary. A Chemist relocating to a no-tax state like Texas, Florida, or Tennessee would retain that amount without changing gross pay.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $116K by 2030.
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The median Chemist salary in San Francisco, CA is $116,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the San Francisco–CA metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Chemists in San Francisco with 0–2 years of experience typically earn between $84,000 and $116,000 annually. Mid-career professionals with 3–7 years command $116,000 to $157,000, while senior-level practitioners with 8+ years of experience regularly earn $157,000 to $206,000 or more.
San Francisco has a cost of living index of 224 compared to the US national average of 100. San Francisco's cost of living is above the US average, so the salary figures above reflect local market rates. California has a 9.3% state income tax rate.
Bachelor's or PhD in Chemistry. 22% of these roles offer some remote flexibility.