Manage clinical trials ensuring protocols are followed and data is collected accurately. Median salary in Sioux Falls: $55K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in Sioux Falls, South Dakota. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Clinical Research Coordinators in Sioux Falls earn approximately 11% lower than the US national median for this role — a $7,000 discount on annual base salary. Sioux Falls's lower wage level partially reflects the area's cost-of-living index of 88 (US avg = 100).
South Dakota has no state income tax, which is worth roughly $5,115 per year at this salary level compared to a California Clinical Research Coordinator on the same gross pay. A Sioux Falls Clinical Research Coordinator would need to earn $60,639 in California to net the same take-home.
Average 1-bedroom rent in Sioux Falls ($1,150/mo) consumes approximately 36% of an after-tax median Clinical Research Coordinator salary. Financial planners typically recommend keeping housing under 30% of take-home — a salary at the 75th percentile ($70K) brings that ratio into a more comfortable range here.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $55K by 2030.
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The median Clinical Research Coordinator salary in Sioux Falls, SD is $55,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the Sioux Falls–SD metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Clinical Research Coordinators in Sioux Falls with 0–2 years of experience typically earn between $42,000 and $55,000 annually. Mid-career professionals with 3–7 years command $55,000 to $70,000, while senior-level practitioners with 8+ years of experience regularly earn $70,000 to $90,000 or more.
Sioux Falls has a cost of living index of 88 compared to the US national average of 100. This means your salary goes approximately 12% further in Sioux Falls than the national average. Crucially, South Dakota has no state income tax — giving Sioux Falls-based Clinical Research Coordinators an immediate 3–5% take-home pay advantage over workers in states like California (9.3%) or New York (6.85%).
Bachelor's in Life Sciences; ACRP or SOCRA certification. 20% of these roles offer some remote flexibility.