Practice medicine under physician supervision — diagnosing, treating, and prescribing. Median salary in Sioux Falls: $114K/year. Data from BLS, O*NET, and H-1B disclosures.
Figures represent annual base salary in Sioux Falls, South Dakota. Reviewed by SalaryOptics Editorial · How we calculate this →
Analysis derived from the salary, COL, tax, and labor-market figures above — specific to this role and city.
Physician Assistants in Sioux Falls earn approximately 12% lower than the US national median for this role — a $16,000 discount on annual base salary. Sioux Falls's lower wage level partially reflects the area's cost-of-living index of 88 (US avg = 100).
South Dakota has no state income tax, which is worth roughly $10,602 per year at this salary level compared to a California Physician Assistant on the same gross pay. A Sioux Falls Physician Assistant would need to earn $125,689 in California to net the same take-home.
Only 5% of Physician Assistant positions offer remote flexibility, meaning the Sioux Falls salary above represents what local employers actually pay — not a remote-anywhere rate. Geographic constraints reinforce the local market, so the salary range above is more directly applicable than for remote-friendly roles.
Based on BLS 2022–2032 Employment Projections and WEF Future of Jobs Report 2026. At current growth rates, median salary reaches $136K by 2030.
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The median Physician Assistant salary in Sioux Falls, SD is $114,000 per year as of Q1 2026. This figure represents the midpoint of all reported compensation for this role in the Sioux Falls–SD metropolitan area, based on data from the Bureau of Labor Statistics Occupational Employment Statistics, H-1B visa disclosures from the Department of Labor, and O*NET occupational data.
Entry-level Physician Assistants in Sioux Falls with 0–2 years of experience typically earn between $95,000 and $114,000 annually. Mid-career professionals with 3–7 years command $114,000 to $136,000, while senior-level practitioners with 8+ years of experience regularly earn $136,000 to $163,000 or more.
Sioux Falls has a cost of living index of 88 compared to the US national average of 100. This means your salary goes approximately 12% further in Sioux Falls than the national average. Crucially, South Dakota has no state income tax — giving Sioux Falls-based Physician Assistants an immediate 3–5% take-home pay advantage over workers in states like California (9.3%) or New York (6.85%).
Master's in Physician Assistant Studies; PA-C certification. 5% of these roles offer some remote flexibility.